Archives for the month of: May, 2010

A new technique can simultaneously sequence DNA and pinpointsome of the chemical modifications that turn genes on or off, according to a report published 9 May in Nature Methods.

In particular, the technique reveals methyl groups bound to DNA bases. DNA methylation — one of several types of ‘epigenetic’ changes — allows organisms to express genes at various times, and in different tissues, without changing the underlying DNA code.

Epigenetic changes, which are influenced by environmental factors such as diet, may be important in autism. Candidate genes account for less than 10 percent of all cases of the disorder.

“Epigenetics is that extra layer on top of the genetic code,” says Janine LaSalle, professor of medical microbiology and immunology at the University of California, Davis. “For a complex disorder like autism that’s a combination of multiple genetic risk factors and environmental risk factors, epigenetics is right there where the action is.”

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SFARI, May 2010.

Given the dearth of drugs available for children with autism, it’s no surprise that many parents turn to complementary and alternative medicine, such as restrictive diets or vitamins.

A new survey finds that, in fact, more than one in every five children with autism uses unconventional treatments. That figure is considerably higher than 12 percent, the estimated proportion of all children in the U.S. who use alternative medicine.

At the Pediatric Academic Societies annual meeting in Vancouver on 2 May, researchers from the Autism Treatment Network said that of 1,212 children with autism they surveyed, 21 percent take at least one type of alternative medicine, and 17 percent eat special diets, usually those without gluten and casein.

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SFARI, May 2010.

Mirror neurons, which fire when someone either performs an action or observes it, are not defective in people with autism, scientists report today in Neuron.

The findings dispute the theory, first proposed a decade ago, that flaws in the mirror neuron system give rise to the disorder.

“The theory is that if the system is fundamentally busted, then these individuals would follow a dramatically different developmental trajectory, and that could lead to autism — but that’s not what we observed,” says lead investigator David Heeger, professor of psychology and neural science at New York University.

The researchers found no significant difference in the average activity of mirror neurons in participants with autism compared with healthy controls when the groups either looked at a series of hand gestures or performed them.

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SFARI, May 2010.

A couple of years ago, researchers in Sweden and Minnesota independently announced the same startling observation: children of Somali immigrants have higher rates of autism than do children of other ethnicities.

A follow-up study by the Swedish group, published 5 March in Acta Paediatricaupends the controversial notion that these clusters are a result of low levels of vitamin D.

The theory goes like this: Women in Somalia are exposed to tons of sunlight — the body’s main source of vitamin D — and consequently make vitamin D more slowly than do light-skinned women. When Somali women immigrate to northern latitudes, they see much less sunlight. If they make much less vitamin D during pregnancy, then their children could wind up with autism.

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SFARI, May 2010.

Neuroscientists have discovered a population of cells in the smell-perception area of the rat brain that express the hormone vasopressin. Blocking vasopressin in this region, called the olfactory bulb, impairs the animals’ ability to recognize other rats by smell, the study found.

Vasopressin plays vital roles in many body tissues, such as regulating water absorption in the kidneys and salt content in the blood.

But in the past few years, the hormone has attracted attention for its role in complex social behaviors. For instance, some studies have found that individuals with autism, who have impaired personal relationships, have increased levels of vasopressin in blood plasma compared with healthy controls.

The new rat work, published 18 March in Nature, adds to several rodent studies showing that vasopressin and its sister brain chemical, oxytocin, control a range of social and reproductive behaviors, from wooing a mate to caring for pups. After years of striking discoveries in animals, geneticists and neuroscientists are beginning to take a closer look at how the hormones affect human social behavior, according to a review published 25 March in Neuron.

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SFARI, May 2010.

Autism is a complex spectrum of disorders, and it’s not at all uncommon for children with the disorder tend to have other psychiatric problems: attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder, anxiety and mood disorders, among others.

In fact, 95 percent of these children have at least three other psychiatric disorders, and 74 percent have five or more, according to a study in the Journal of Autism and Developmental Disorders.

More than 80 percent of kids with autism have ADHD, making it the most common co-diagnosis; 61 percent have two or more anxiety disorders — notably, agoraphobia — and 56 percent have major depression.

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SFARI, May 2010.

There’s an important difference between hearing words spoken and actually listening. The latter is all but impossible for children with a rare and little-studied condition called auditory processing disorder (APD).

No one knows what causes the condition, defined by the inability to recognize and interpret sounds. It appears in an estimated two to five percent of children, and is only beginning to get a bit of public attention.

Last week, speech pathologist Lois Kam Heymann published a book about APD called The Sound of Hope. The book has made a splash thanks to comedian Rosie O’Donnell, who wrote about her 10-year-old son’s struggle with the disorder in the book’s foreword.

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SFARI, May 2010.