Archives for the month of: February, 2010

In 1943, psychiatrist Leo Kanner described 11 children who preferred to be alone and ignored people around them. Some of the children didn’t respond to direct questions, others used the pronouns ‘you’ or ‘he’ instead of ‘I’. Kanner called the children ‘autistic’, from the Greek word ‘autos’, or self.

A team of cognitive scientists at University of Cambridge has uncovered a brain signature of this abnormal self-representation in people with autism. Using functional magnetic resonance imaging, the team found that when thinking about themselves, adults with autism have lower activity in two specific brain regions important for decision-making and social interactions than do healthy controls.

What’s more, individuals with autism have weaker connections between one of these areas, the ventromedial prefrontal cortex (vMPFC), and regions harboring mirror neurons, cells that fire either when a person performs or observes a given action. The report — only the second imaging study to address the concept of ‘self’ in people with autism — was published in the February issue of Brain.

Read more at…

SFARI, February 2010.

The motley mix of abilities and disabilities among individuals with autism is reflected in the long list of their diagnoses: there are, among many others, the classic ‘autistic disorder’, Asperger syndrome — for individuals with strong verbal and cognitive abilities — and ‘pervasive developmental disorder not otherwise specified’, sort of a catch-all category for people with developmental delay who don’t quite meet the strict criteria for autism.

Last week, the psychiatrists who literally write the book on the definitions of mental illness announced their plan to roll all of these conditions into a single category of ‘autism spectrum disorder.’ It’s one of many major changes they aim to make in the encyclopedic Diagnostic Manual of Mental Disorders (DSM), expected to come out in 2013.

Read more at…

SFARI, February 2010.

For the title of best animal models, lab rats may be facing some competition from man’s best friends: dogs.

Canines and humans get many of the same diseases, and often respond to the same drug treatments. Dogs also tend to mimic the symptoms and pathology of human disease much more closely than rodents do.

“Understanding the underlying genetics in dogs is almost certain to enlighten us about the human condition,” notes Elaine Ostrander, chief of the Cancer Genetics Branch at the National Human Genome Research Institute.

Read more at…

SFARI, February 2010.

A class of medications widely used during pregnancy to treat asthma and prevent early labor increases the baby’s risk of autism and other psychiatric disorders, according to a controversial review in the American Journal of Obstetrics and Gynecology.

The review, published in the journal’s December issue, proposes that long-term exposure to the drugs — called beta-2 adrenergic (B2A) agonists — during key periods of brain development can send the nervous system into overdrive, eventually giving rise to autism.

Read more at…

SFARI, February 2010.

Older men have a higher risk of fathering a child with autism, but — get this — only when their mate is younger than 30. So says the newest study to weigh in on the perennial debate about parental age and autism.

The report is not simply a warning to men about robbing the cradle. It’s part of a wave of new research on autism risk that’s shifting the focus from older fathers to older mothers.

Last September, using data from millions of California births in the 1990s, a group showed that women over 40 are nearly twice as likely to have a child with autism than those under 30. They also showed that the risk varies greatly from year to year.

The new study, published online Monday in Autism Research, draws from the same massive California dataset. It found that regardless of the father’s age, women over 40 are 77 percent more likely to deliver a child with autism than those younger than 25, and 51 percent more likely than those aged 25 to 29.

Read more at…

SFARI, February 2010.

We hear a lot about the prevalence of autism, but here’s a remarkable statistic you may not have heard: white children are two to three times more likely to be diagnosed with the disorder than are their Hispanic peers.

You may think the simplest explanation is economics. And it’s true that, compared with white families, Hispanic families are less likely to have health insurance and a regular doctor, and more likely to fall below the poverty line.

But the autism disparity remains even when researchers account for those socioeconomic differences, according to a study out this month in the American Journal of Public Health.

Read more at…

SFARI, February 2010.

Individuals who carry a large and rare deletion on chromosome 16 that is associated with autism are likely to have developmental delay, be obese, or both, according to two studies published last week in Nature.

The deletion, known briefly as 16p, covers a 25-gene stretch of chromosomal region 16p11.2. It crops up in roughly 0.6 percent of all cases of autism. Some studies have found the variant in individuals with other psychiatric conditions, such as schizophrenia and bipolar disorder, and even in healthy controls.

The new reports are the first to search for obesity-related rare variants across the genome and the first to link 16p — or any other rare DNA deletion or duplication — to obesity.

Read more at…

SFARI, February 2010.

There’s good news for autism research tucked into President Obama’s 2011 budget proposal: $222 million of it, to be exact.

That generous sum is part of the $32.1 billion the president has allocated to the National Institutes of Health (NIH). Last year, the NIH received about $31 billion, plus the one-time gift of about $10 billion from the hefty stimulus package.

The new NIH budget calls for autism funding “to expand research, detection, treatment, and other activities” related to improving the lives of individuals with the disorder.

Read more at…

SFARI, February 2010.

Genetic variations that tweak the brain’s release of oxytocin — a hormone involved in social bonding and establishing trust — may increase the risk of developing autism or autistic traits, according to three new studies published in the past few months.

One of the studies also finds, for the first time, that oxytocin regulation in people with autism is partly controlled by epigenetic changes, which can turn genes on or off without altering the underlying code.

Oxytocin has been linked to autism for nearly two decades, and the hormone is already being doled out in several small clinical trials to treat the disorder. But the new reports are part of a growing wave of interest in the precise nature of its involvement.

“The field is really new,” says Sue Carter, professor of psychiatry at University of Illinois at Chicago, who was not involved in either new study.

Read more at…

SFARI, February 2010.